THC-A: A better anti-inflammatory and neuro-protectant

While there has been a lot of discussion in the literature, both lay and scientific, about the properties of Cannabidiol (CBD) as an anti-inflammatory and neuroprotectant, there are significant problems with CBD in reality.

Tetrahydrocannabinolic acid (THC-A) is another cannabinoid or cannabis-derived medication that has yet to get the attention it truly deserves. THC-A presents an option that is similar to CBD but better!

Aside from what CBD appears to be able to treat, its main attraction is that it is non-intoxicating (meaning it doesn’t get you high). On the downside, however, the amount of CBD you need to take to get the benefits described in medical studies is 500-1500mg per day or about $30-80 US per day. This is pretty much a show stopper for most patients.

THC-A is abundant

Even if you could afford it, these doses are just hard to find. The reason is that CBD is not very abundant in cannabis or hemp. There are some strains that produce more CBD, but it’s still not very much. THC-A, on the other hand, is what cannabis produces readily. In fact, when you buy good old cannabis flower for whatever purpose, it has nearly no THC in it! What it has is THC-A. Lots of it. It is only when we heat the THC-A, by cooking or burning it, for examples, that it converts to THC. Using a cold extraction technique, like chilled ethanol, can produce vast amounts of THC-A for use. Yes, you can do this at home! <link to recipe>

THC-A is a potent antioxidant. As a result, there may be some rationale for using it as a neuroprotectant in diseases like Alzheimer’s, Parkinson’s, Multiple Sclerosis, ALS, and similar. This has NOT yet been tested in humans, but the theory is reasonable.

THC-A is a potent anti-inflammatory. In cell culture of human tissue as well as in mouse models of inflammatory bowel disease, THC-A has been shown to be very effective. In fact, it’s felt to be 10-20x as potent as CBD. Further, CBD in high doses can kill affected cells, whereas THC-A does not. So, THC-A is stronger and more effective.

Doesn’t interact with other medications?

Worth noting as well, CBD is broken down by the liver by an enzyme that breaks down many common conventional medications. As a result, CBD can interact with these medications, sometimes in potentially dangerous ways. For my more complicated patients, this is a significant concern. THC-A, on the other hand, is broken down by an enzyme that is relatively lonely and has not much better to do than take care of the THC-A. As a result, interactions are much less likely.

There are two major downsides to THC-A: First, despite being wildly abundant in cannabis, it is not commonly available at dispensaries yet. This will change as awareness and research increase. In the meantime, see the home version instructions above. Second, there is fairly little known at this time about how much to use. Best estimates appear to be between 10-40mg twice a day. However, given that it is non-intoxicating and safer than CBD, it is reasonable to titrate the dose slowly to best effect. This should be done very slowly over many weeks as research indicates that the benefit takes a while to accrue, possibly as long as 6 weeks for maximum effect.

If you have an auto-immune illness like Crohn’s or RA, I would suggest that you consider THC-A. I would certainly advise THC-A over CBD in these illnesses.

The article is written by Dr. Jordan Tishler, the CEO of inhaleMD, a cannabis medicine clinic in Massachusetts. The article first appeared on inhaleMD’s website. Through his training in Internal Medicine and years of practice as an Emergency Physician, Dr. Tishler brings his knowledge, reason, and caring to patients here at inhaleMD, and through his advocacy work at the local and national levels.